By Laura Dyrda Total knee replacement surgery price varies by geographic region. The total price includes hospital services, physician services and anesthesia, according to Healthcare Blue Book. The hospital services assume a four day admission and the physician fee is for the procedure and routine postoperative care. The anesthesia price assumes average surgery time of 2 1/2 hours. Here are the prices for the 20 largest cities based on population from the 2010 U.S. Census.